Aminotonic Plus

It is a dietary supplement of essential amino acids specific for preterm infants or SGA.

Aminotonic Plus allows to make an increase not only quantitative, but especially qualitative to the protein amount of infant formula to promote protein synthesis and growth of tissues.

For preterm infants the quality of the “protein” (understood as the content of essential amino acids) is as important as the quantity, due to immaturity of the gastrointestinal tract and liver. (1)

(1) Scientifically-based strategies for nutrition of the high-risk low birth weight infant. Neu J, Valentine C, Meetze W. Eur J Pediatr. 1990 Nov;150(1):2-13.

Aminotonic Plus contains:

  • the nine essential amino acids (isoleucine, leucine, valine, lysine, methionine, phenylalanine, threonine, tryptophan and histidine);
  • cysteine and tyrosine, which are essential in preterm infants due to the inability of the body to produce them;
  • glutamic acid, important for the synthesis of glutathione with antioxidant function.

Supplementation with essential amino acids showed a recovery of extra-uterine growth retardation and a faster growth in terms of weight, length and head circumference.

For more information, see SCIENTIFIC EVIDENCES.

Dietary supplements are not intended as a substitute for a varied, balanced diet and healthy lifestyle.

Aminotonic Plus does not induce overload of metabolic functions and provides essential amino acids readily absorbed.

The value of osmolarity of Aminotonic Plus allows its use also in addition to infant formula for preterm infants: the osmolarity of Aminotonic Plus for one sachet dissolved in 100 ml of water is equal to 44 mOsm/l.

Dosage: 2 sachets daily, unless otherwise indicated by your doctor.

How to use: Dissolve 1 sachet in 20 ml of water or 75 ml of milk.

Packaging: 20 sachets of 1 gram.

Storage: Store at room temperature in a cool, dry place. Avoid exposure to sources of localized heat, direct sunlight and contact with water. The expiration date refers to the product properly stored. Any slight variation in color is not an indication of quality deterioration of the product. Do not throw out into the environment after use.

Warnings: Do not exceed the recommended daily dose. Keep out of the reach of children under three years hold. Dietary supplements are not intended as a substitute for a varied, balanced diet and healthy lifestyle. You must consult your doctor in case of prolonged use (over 6-8 weeks). If you suffer from liver or kidney, pregnant women and children under 12 years old, consult your doctor before use.

Ingredients: Maltodextrin, L-Lysine hydrochloride, L-Leucine, L-Glutamic acid, lemon flavor, L-Phenylalanine, L-Isoleucine, L-Valine, L-Threonine, L-Histidine hydrochloride, citric acid, L-Methionine , L-Tyrosine, L-Tryptophan, L-Cysteine ​​hydrochloride, anti-caking agent: silicon dioxide.


 Ingredients For 100 g For 2 sachets
Maltodextrin 40 g 800 mg
L-Lisin 7,75 g 155 mg
L-Leucin 7,75 g 155 mg
L-Glutammic acid 7,5 g 150 mg
L-Phenilalanin 4,5 g 90 mg
L-Isoleucin 4,3 g 86 mg
L-Valin 4,3 g 86 mg
L-Treonin 3,5 g 70 mg
L-Methionin 2,25 g 45 mg
L-Histidin 2 g 40 mg
L-Tirosin 1,5 g 30 mg
L-Triptofan 1,4 g 28 mg
L-Cistein 1 g 20 mg


ESPGHAN guidelines for preterm infants

The preterm infants need a protein supplement to make up for the protein deficit up to a maximum of 4.5 g/kg day, an intake higher than that indicated showed no adverse effects in these patients, but a small deficit reduces the growth.

It is recommended that a protein intake of 4-4.5 g/kg/day for infants weighing less than 1 kg and 3.5-4 g/kg/day for infants weighing between 1 kg and 1.8 kg.

SOURCE: Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition. C. Agostoni et al.Journal of Pediatric Gastroenterology and Nutrition 2010 50:1–9.


The essential amino acids prevent the extra-uterine growth retardation in VLBW infants: preliminary data from a double-blind placebo-controlled

In a randomized, double-blind, placebo-controlled VLBW infants (very low weight) received enteral supplementation of essential amino acids (0.8 g/kg/day) or placebo, from the third day after birth until discharge.

Were evaluated as a benchmark weight, length and head circumference.

The results showed that supplementation with essential amino acids would appear to reduce the delay of extrauterine growth in VLBW infants.

SOURCE: Essential amino acids prevent the extrauterine growth retardation in Very low birth weight infants. Preliminar data of a double blind randomized controlled trial. G. Salvia, A. Umbaldo, V. Fonterico, G. Mazzarella, S.Moschella, D. Zappulli. JPGN Volume 50, Suppl 2, June 2010.